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2016




Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A.

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 Nov;22(11):1321-1329. doi: 10.1038/nm.4213.



Kohnz RA, Roberts LS, DeTomaso D, Bideyan L, Yan P, Bandyopadhyay S, Goga A, Yosef N, Nomura DK.

Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity.

ACS Chem Biol. 2016 Aug 19;11(8):2131-9. doi: 10.1021/acschembio.6b00433.



Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK.

GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity.

Cell Chem Biol. 2016 May 19;23(5):567-78. doi: 10.1016/j.chembiol.2016.03.017.


Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.  Nature Medicine 2016 Mar 7. doi: 10.1038/nm.4055. [Epub ahead of print]

 


2015



Devon A. Lawson, Nirav R. Bhakta, Kai Kessenbrock, Karin D. Prummel, Ying Yu, Ken Takai, Alicia Zhou, Henok Eyob, Sanjeev Balakrishnan, Chih-Yang Wang, Paul Yaswen, Andrei Goga* & Zena Werb* Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature, October 1, 2015   *co-corresponding



Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, McManus MT. Biogenesis, delivery, and function of extracellular RNA.

J Extracell Vesicles. 2015 Aug 28;4:27494. doi: 10.3402/jev.v4.27494. eCollection 2015.


Evason KJ*, Francisco MT, Juric V, Balakrishnan S, Lopez Pazmino MD, Gordan JD, Kakar S, Spitsbergen J, Goga A*, Stainier DY*. Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.  PLoS Genet. 2015 Jul 2;11(7):e1005305. doi: 10.1371/journal.pgen.1005305. eCollection 2015 Jul.  PMID: 26134322

* co-corresponding


Brondfield S, Umesh S, Corella A, Zuber J, Rappaport AR, Gaillard C, Lowe SW, Goga A, Kogan SC. Direct and indirect targeting of MYC to treat acute myeloid leukemia. Cancer Chemother Pharmacol. 2015 Jul;76(1):35-46. doi: 10.1007/s00280-015-2766-z. Epub 2015 May 9.

PMID: 25956709


Kohnz RA, Mulvihill MM, Chang JW, Hsu KL, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK. Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer. ACS Chem Biol. 2015 May 7. [Epub ahead of print]  PMID: 25945974


Noelle E. Huskey, Tingxia Guo, Kimberley J. Evason, Olga Momcilovic, David Pardo, Katelyn J. Creasman, Robert Judson, Robert Blelloch, Scott A. Oakes, Matthias Hebrok and Andrei Goga.  CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation.  Stem Cell Reports (2015), http://dx.doi.org/10.1016/j.stemcr.2015.01.019



Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, M Shokat KM, McCormick F, Goga A*, Bandyopadhyay S*. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.  Cancer Discovery Feb, 2015

  1. *co-corresponding

 




Horiuchi D, Anderton B, Goga ATaking on challenging targets: making MYC druggable.  Am Soc Clin Oncol Educ Book. 2014:e497-502. doi: 10.14694/EdBook_AM.2014.34.e497.


Hoellein A, Fallahi M, Schoeffmann S, Steidle S, Schaub FX, Rudelius M, Laitinen I, Nilsson L, Goga A, Peschel C, Nilsson JA, Cleveland JL, Keller U. Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma.  Blood. 2014 Sep 25;124(13):2081-90. doi: 10.1182/blood-2014-06-584524.


Benjamin DI, Louie SM, Mulvihill MM, Kohnz RA, Li DS, Chan LG, Sorrentino A, Bandyopadhyay S, Cozzo A, Ohiri A, Goga A, Ng SW, Nomura DK.

Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism that Drives Cancer Aggressiveness.  ACS Chem Biol. 2014 Apr 16. PMID: 24738946


Chien AJ, Munster PN, Melisko ME, Rugo HS, Park JW, Goga A, Auerback G, Khanafshar E, Ordovas K, Koch KM, Moasser MM. Phase I Dose-Escalation Study of 5-Day Intermittent Oral Lapatinib Therapy in Patients With Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer.  J Clin Oncol. 2014 Apr 14. PMID: 24711549


Balko JM, Giltnane JM, Wang K, Schwarz LJ, Young CD, Cook RS, Owens P, Sanders ME, Kuba MG, Sánchez V, Kurupi R, Moore PD, Pinto JA, Doimi FD, Gómez H, Horiuchi D, Goga A, Lehmann BD, Bauer JA, Pietenpol JA, Ross JS, Palmer GA, Yelensky R, Cronin M, Miller VA, Stephens PJ, Arteaga CL.  Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.

Cancer Discov. 2014 Feb;4(2):232-45.


Lim L, Balakrishnan A, Huskey N, Jones KD, Jodari M, Ng R, Song G, Riordan J, Anderton B, Cheung ST, Willenbring H, Dupuy A, Chen X, Brown D, Chang AN, Goga A.  MiR-494 within an oncogenic MicroRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of MCC.  Hepatology. 2014 Jan;59(1):202-15.  PMID: 23913442


2013




Olive V, Sabio E, Bennett MJ, De Jong CS, Biton A, McGann JC, Greaney SK, Sodir NM, Zhou AY, Balakrishnan A, Foth M, Luftig MA, Goga A, Speed TP, Xuan Z, Evan GI, Wan Y, Minella AC, He L.  (2013).  A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.  Elife. 2013 Oct 15;2:e00822.


Juang, B.-T. , Gu, C., Starnes, L., Palladino, F., Goga, A., Kennedy, S., L'Etoile, N.D. (2013). Endogenous Nuclear RNAi Mediates Behavioral Adaptation to Odor. Cell. 2013 Aug 29;154(5):1010-22. PMID: 23993094



Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med. 2013 Feb 14. doi: 10.1002/mrm.24634.

 

2012




Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 9;338(6108):818-22.


Amin DN, Sergina N, Lim L, Goga A, Moasser MM. HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells. Biochem J. 2012 Nov 1;447(3):417-25. doi: 10.1042/BJ20120724.


Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7.


Horiuchi D*, Huskey NE*, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat KM, Fisher RP, Goga A. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.  Proc Natl Acad Sci U S A. 2012 Apr 3. [Epub ahead of print]

*Contributed Equally.


Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV, Smyth JW, Davis SE, Yaswen P, Mills GB, Esserman LJ, Goga A. MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J. Exp. Medicine.  2012.  doi:10.1084/jem.20111512


von Morze C, Larson PE, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB.  Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea.  Magn Reson Imaging. 2012 Apr;30(3):305-11.

 
2011

Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A. (13)C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression.  Cell Metab. 2011 Jul 6;14(1):131-42.


Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP.  Switching cdk2 on or off with small molecules to reveal requirements in human cell proliferation.  Mol Cell. 2011 Jun 10;42(5):624-36.  PMID: 21658603


von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging. 2011 Mar;33(3):692-7. doi: 10.1002/jmri.22484. PMID: 21563254


Chow EK, Zhang XQ, Chen M, Lam R, Robinson E, Huang H, Schaffer D, Osawa E, Goga A, Ho D.  Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment.  Sci Transl Med. 2011 Mar 9;3(73):73ra21.  PMID: 21389265



2010

Swarbrick A, Woods SL, Shaw A, Balakrishnan A, Phua Y, Nguyen A, Chanthery Y, Lim L, Ashton LJ, Judson RL, Huskey N, Blelloch R, Haber M, Norris MD, Lengyel P, Hackett CS, Preiss T, Chetcuti A, Sullivan CS, Marcusson EG, Weiss W, L'Etoile N, Goga A. miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma. Nat Med. 2010 Oct;16(10):1134-40.


den Hollander J, Rimpi S, Doherty JR, Rudelius M, Buck A, Hoellein A, Kremer M, Graf N, Scheerer M, Hall MA, Goga A, von Bubnoff N, Duyster J, Peschel C, Cleveland JL, Nilsson JA, Keller U. Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state. Blood. 2010 Sep 2;116(9):1498-505.


Yang D, Liu H, Goga A, Kim S, Yuneva M, Bishop JM. Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13836-41.


Lee JI, O'Halloran DM, Eastham-Anderson J, Juang BT, Kaye JA, Scott Hamilton O, Lesch B, Goga A, L'Etoile ND. Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6016-21.


Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB. 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med. 2010 Feb;63(2):312-21.


 

2009


Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT. Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. J Biol Chem. 2009 Jul 3;284(27):18515-24.


Kaye JA, Rose NC, Goldsworthy B, Goga A, L'Etoile ND. A 3'UTR pumilio-binding element directs translational activation in olfactory sensory neurons. Neuron. 2009 Jan 15;61(1):57-70. PubMed PMID: 19146813.



2008


Cairo S, Armengol C, De Reyniès A, Wei Y, Thomas E, Renard CA, Goga A, Balakrishnan A, Semeraro M, Gresh L, Pontoglio M, Strick-Marchand H, Levillayer F, Nouet Y, Rickman D, Gauthier F, Branchereau S, Brugières L, Laithier V, Bouvier R, Boman F, Basso G, Michiels JF, Hofman P, Arbez-Gindre F, Jouan H, Rousselet-Chapeau MC, Berrebi D, Marcellin L, Plenat F, Zachar D, Joubert M, Selves J, Pasquier D, Bioulac-Sage P, Grotzer M, Childs M, Fabre M, Buendia MA. Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer. Cancer Cell. 2008 Dec 9;14(6):471-84. PubMed PMID: 19061838.



2007


Goga A, Benz C. Anti-oncomir suppression of tumor phenotypes. Mol Interv. 2007 Aug;7(4):199-202, 180. PubMed PMID: 17827440.


Goga A, Yang D, Tward AD, Morgan DO, Bishop JM. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med. 2007 Jul;13(7):820-7.


Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS, Benz CC. Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J Biol Chem. 2007 Jan 12;282(2):1479-86. 

 

Prior Publications:


Yang D, Goga A, Bishop JM. RNA interference (RNAi) with RNase III-prepared siRNAs. Methods Mol Biol. 2004;252:471-82. PubMed PMID: 15017072.


Yang D, Buchholz F, Huang Z, Goga A, Chen CY, Brodsky FM, Bishop JM. Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9942-7. 


Moro M, Walkenhorst J, Goga A, Witte ON, Superti-Furga G. A functional screen for regulators of the c-Abl protein tyrosine kinase. Leukemia. 1997 Apr;11 Suppl 3:313-5. PubMed PMID: 9209375.


Golub TR, Goga A, Barker GF, Afar DE, McLaughlin J, Bohlander SK, Rowley JD, Witte ON, Gilliland DG. Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia. Mol Cell Biol. 1996 Aug;16(8):4107-16. PubMed PMID: 8754809; PubMed Central PMCID: PMC231407.


Walkenhorst J, Goga A, Witte ON, Superti-Furga G. Analysis of human c-Abl tyrosine kinase activity and regulation in S. pombe. Oncogene. 1996 Apr 4;12(7):1513-20. PubMed PMID: 8622867.


Goga A, McLaughlin J, Afar DE, Saffran DC, Witte ON. Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene. Cell. 1995 Sep 22;82(6):981-8. PubMed PMID: 7553858.


Goga A, Liu X, Hambuch TM, Senechal K, Major E, Berk AJ, Witte ON, Sawyers CL. p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase. Oncogene. 1995 Aug 17;11(4):791-9. PubMed PMID: 7651743.


Cohen L, Mohr R, Chen YY, Huang M, Kato R, Dorin D, Tamanoi F, Goga A, Afar D, Rosenberg N, et al. Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12448-52. PubMed PMID: 7809057; PubMed Central PMCID: PMC45455.


Afar DE, Goga A, McLaughlin J, Witte ON, Sawyers CL. Differential complementation of Bcr-Abl point mutants with c-Myc. Science. 1994 Apr 15;264(5157):424-6. PubMed PMID: 8153630.


Sawyers CL, McLaughlin J, Goga A, Havlik M, Witte O. The nuclear tyrosine kinase c-Abl negatively regulates cell growth. Cell. 1994 Apr 8;77(1):121-31. PubMed PMID: 7512450.


Afar DE, Goga A, Cohen L, Sawyers CL, McLaughlin J, Mohr RN, Witte ON. Genetic approaches to defining signaling by the CML-associated tyrosine kinase BCR-ABL. Cold Spring Harb Symp Quant Biol. 1994;59:589-94. Review. PubMed PMID: 7587117.


Goga A, McLaughlin J, Pendergast AM, Parmar K, Muller A, Rosenberg N, Witte ON. Oncogenic activation of c-ABL by mutation within its last exon. Mol Cell Biol. 1993 Aug;13(8):4967-75.

 

2017





Anderton B, Camarda R, Balakrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A.

MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.

EMBO Rep. 2017 Feb 20. pii: e201643068. doi: 10.15252/embr.201643068. [Epub ahead of print]

PMID: 28219903




Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB.

Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques.

Magn Reson Imaging. 2017 Jan 7;38:152-162. doi: 10.1016/j.mri.2017.01.003. [Epub ahead of print]